This research applies an automated mesoscale convective system (MCS) segmentation, classification, and tracking approach to composite radar reflectivity mosaic images that cover the contiguous United States (CONUS) and span a relatively long study period of 22 years (1996–2017). These data afford a novel assessment of the seasonal and interannual variability of MCSs. Additionally, hourly precipitation data from 16 of those years (2002–17) are used to systematically examine rainfall associated with radar-derived MCS events. The attributes and occurrence of MCSs that pass over portions of the CONUS east of the Continental Divide (ECONUS), as well as five author-defined subregions—North Plains, High Plains, Corn Belt, Northeast, and Mid-South—are also examined. The results illustrate two preferred regions for MCS activity in the ECONUS: 1) the Mid-South and Gulf Coast and 2) the Central Plains and Midwest. MCS occurrence and MCS rainfall display a marked seasonal cycle, with most of the regions experiencing these events primarily during the warm season (May–August). Additionally, MCS rainfall was responsible for over 50% of annual and seasonal rainfall for many locations in the ECONUS. Of particular importance, the majority of warm-season rainfall for regions with high agricultural land use (Corn Belt) and important aquifer recharge properties (High Plains) is attributable to MCSs. These results reaffirm that MCSs are a significant aspect of the ECONUS hydroclimate.